論文

• Impact of mineralocorticoid receptor blockade with direct renin inhibition in angiotensin II-dependent hypertensive mice.
  Hashimoto A, Takeda Y, Karashima S, Kometani M, Aono D, Demura M, Higashitani T, Konishi S, Yoneda T, Takeda Y.Hashimoto A, et al. Among authors: Yoneda T.Hypertens Res. 2020 May 12.
• Nadir Aldosterone Levels After Confirmatory Tests Are Correlated With Left Ventricular Hypertrophy in Primary Aldosteronism.
  Ohno Y, Sone M, Inagaki N, Kawashima A, Takeda Y, Yoneda T, Kurihara I, Itoh H, Tsuiki M, Ichijo T, Katabami T, Wada N, Sakamoto R, Ogawa Y, Yoshimoto T, Yamada T, Kawashima J, Matsuda Y, Kobayashi H, Kamemura K, Yamamoto K, Otsuki M, Okamura S, Izawa S, Okamoto R, Tamura K, Tanabe A, Naruse M; JPAS/JRAS Study Group.Ohno Y, et al. Among authors: Yoneda T.Hypertension. 2020 Jun;75(6):1475-1482.
• Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome.
  Kobayashi H, Nakamura Y, Abe M, Kurihara I, Itoh H, Ichijo T, Takeda Y, Yoneda T, Katabami T, Tsuiki M, Wada N, Ogawa Y, Sakamoto R, Kawashima J, Sone M, Inagaki N, Yoshimoto T, Yamada T, Okamoto R, Matsuda Y, Fujita M, Watanabe M, Tamura K, Tanabe A, Naruse M; JPAS/JRAS Study Group.Kobayashi H, et al. Among authors: Yoneda T.Eur J Endocrinol. 2020 Mar;182(3):265-273.
• Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan.
  Fujii Y, Takeda Y, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Yamamto K, Ogo A, Yanase T, Okamura S, Miyauchi S, Fujita M, Suzuki T, Umakoshi H, Ogasawara T, Tsuiki M, Naruse M; JPAS Study Group.Fujii Y, et al.J Hum Hypertens. 2020 Jan;34(1):34-42.
• Primary aldosteronism subtype discordance between computed tomography and adrenal venous sampling.
  Aono D, Kometani M, Karashima S, Usukura M, Gondo Y, Hashimoto A, Demura M, Furukawa K, Takeda Y, Kawashiri M, Yoneda T.Aono D, et al. Among authors: Yoneda T.Hypertens Res. 2019 Dec;42(12):1942-1950.
• Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia.
  Kometani M, Yoneda T, Demura M, Aono D, Gondoh Y, Karashima S, Nishimoto K, Yasuda M, Horike SI, Takeda Y.Kometani M, et al. Among authors: Yoneda T.Steroids. 2019 Nov;151:108470.
• Association Between Acute Fall in Estimated Glomerular Filtration Rate After Treatment for Primary Aldosteronism and Long-Term Decline in Renal Function.Kobayashi H, Abe M, Nakamura Y, Takahashi K, Fujita M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Tsuiki M, Wada N, Ichijo T, Katabami T, Ogawa Y, Kawashima J, Yoshimoto T, Sone M, Inagaki N, Watanabe M, Kamemura K, Matsuda Y, Izawa S, Tanabe M, Tanabe A, Suzuki T, Naruse M; JPAS/JRAS Study Group.Kobayashi H, et al. Among authors: Yoneda T.Hypertension. 2019 Sep;74(3):630-638.
• Lateralizing Asymmetry of Adrenal Imaging and Adrenal Vein Sampling in Patients With Primary Aldosteronism.
  Wada N, Shibayama Y, Yoneda T, Katabami T, Kurihara I, Tsuiki M, Ichijo T, Ogawa Y, Kawashima J, Sone M, Yoshimoto T, Matsuda Y, Fujita M, Kobayashi H, Tamura K, Kamemura K, Otsuki M, Okamura S, Naruse M; JPAS/JRAS Study Group.Wada N, et al. Among authors: Yoneda T.J Endocr Soc. 2019 May 16;3(7):1393-1402.
• High Prevalence of Diabetes in Patients With Primary Aldosteronism (PA) Associated With Subclinical Hypercortisolism and Prediabetes More Prevalent in Bilateral Than Unilateral PA: A Large, Multicenter Cohort Study in Japan.　Akehi Y, Yanase T, Motonaga R, Umakoshi H, Tsuiki M, Takeda Y, Yoneda T, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ashida K, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamoto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Hashimoto S, Yamada M, Yoshikawa Y, Kai T, Suzuki T, Kawamura T, Naruse M; Japan Primary Aldosteronism Study Group.Akehi Y, et al. Diabetes Care. 2019 May;42(5):938-945.

• Study Protocol for the Effects of Artificial Intelligence (AI)-Supported Automated Nutritional Intervention on Glycemic Control in Patients with Type 2 Diabetes Mellitus. Oka R, Nomura A, Yasugi A, Kometani M, Gondoh Y, Yoshimura K, Yoneda T.　Diabetes Ther. 　2019/03　査読有　原著論文　研究論文（学術雑誌）
• Madelung disease in a 58-year-old man.
  Karashima S, Yoneda T.　CMAJ. 2019/01査読有 原著論文 研究論文（学術雑誌）
• C-Peptide Area Under the Curve at Glucagon Stimulation Test Predicts Glucose Improvements by GLP-1 Receptor Analogue: A Retrospective Observational Study. 　Ohbatake A, Yagi K, Karashima S, Shima Y, Miyamoto Y, Asaka H, Okazaki S, Kometani M, Kawashiri MA, Takeda Y, Yoneda T, Chujo D. Diabetes Ther. 2019/02査読有 原著論文　研究論文（学術雑誌）
• Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity.
  Wakabayashi Y, Oka R, Nakaya M, Karashima S, Kometani M, Sakurai M, Yoshimura K, Yoneda T.　J Diabetes Res.　2018/10査読有 原著論文 研究論文（学術雑誌）
• Severe Mitral Regurgitation As a Result of Rupture of Mitral Valve Chordae Tendineae in a Patient With Graves Disease.
  Karashima S, Tsuda T, Kometani M, Oka R, Demura M, Kawashiri MA, Takeda Y, Hayashi K, Yoneda T.　J Endocr Soc.　2018/09査読有 原著論文 研究論文(学術雑誌)
• The status of glycemic control and hypoglycemia in elderly patients visiting the outpatient department specializing in diabetes.
  Soma Y, Oka R, Fujii S, Ito N, Kometani M, Karashima S, Takeda Y, Yoneda T, Asano A.　Nihon Ronen Igakkai Zasshi. 　2018/05 査読有原 著論文 研究論文(学術雑誌)
• Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism.
  Kometani M, Yoneda T, Aono D, Karashima S, Demura M, Nishimoto K, Yamagishi M, Takeda Y.　Oncotarget. 　2018/05査読有 原著論文 研究論文(学術雑誌)
• Correlation Between Lateralization Index of Adrenal Venous Sampling and Standardized Outcome in Primary Aldosteronism.
  Umakoshi H, Tsuiki M, Yokomoto-Umakoshi M, Takeda Y, Takashi Y, Kurihara I, Itoh H, Katabami T, Ichijo T, Wada N, Shibayama Y, Yoshimoto T, Ashida K, Ogawa Y, Kawashima J, Sone M, Inagaki N, Takahashi K, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Yanase T, Hashimoto S, Yamada M, Yoshikawa Y, Kai T, Suzuki T, Kawamura T, Naruse M.J Endocr Soc. 2018/05査読有 原著論文 研究論文(学術雑誌)
• Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II.　Takeda Y, Demura M, Wang F, Karashima S, Yoneda T, Kometani M, Hashimoto A, Aono D, Horike SI, Meguro-Horike M, Yamagishi M, Takeda Y.　J Am Heart Assoc.　2018/05査読有 原著論文 研究論文(学術雑誌)
• Prevalence of Cardiovascular Disease and Its Risk Factors in Primary Aldosteronism: A Multicenter Study in Japan.
  Ohno Y, Sone M, Inagaki N, Yamasaki T, Ogawa O, Takeda Y, Kurihara I, Itoh H, Umakoshi H, Tsuiki M, Ichijo T,Katabami T, Tanaka Y, Wada N, Shibayama Y, Yoshimoto T, Ogawa Y, Kawashima J, Takahashi K, Fujita M, Watanabe M, Matsuda Y, Kobayashi H, Shibata H, Kamemura K, Otsuki M, Fujii Y, Yamamoto K, Ogo A, Okamura S, Miyauchi S, Fukuoka T, Izawa S, Yoneda T, Hashimoto S, Yanase T, Suzuki T, Kawamura T, Tabara Y, Matsuda F, Naruse M; Nagahama Study; JPAS Study Group. Hypertension. 2018 Mar;71(3):530-537. (査読あり)
• The Occurrence of Apparent Bilateral Aldosterone Suppression in Adrenal Vein Sampling for Primary Aldosteronism.
  Shibayama Y, Wada N, Naruse M, Kurihara I, Ito H, Yoneda T, Takeda Y, Umakoshi H, Tsuiki M, Ichijo T, Fukuda H, Katabami T, Yoshimoto T, Ogawa Y, Kawashima J, Ohno Y, Sone M, Fujita M, Takahashi K, Shibata H, Kamemura K, Fujii Y, Yamamoto K, Suzuki T. J Endocr Soc. 2018 Mar 22;2(5):398-407. (査読あり)
• Effect of sodium glucose cotransporter 2 inhibitors on obstructive sleep apnea in patients with type 2 diabetes.
  Sawada K, Karashima S, Kometani M, Oka R, Takeda Y, Sawamura T, Fujimoto A, Demura M, Wakayama A, Usukura M, Yagi K, Takeda Y, Yoneda T. Endocr J. 2018;65(4):461-467. (査読あり)
• Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index.
  Aono D, Oka R, Kometani M, Takeda Y, Karashima S, Yoshimura K, Takeda Y, Yoneda T. J Diabetes Res. 2018:5107589. Doi: 10.1155/2018/5107589. (査読あり)
• Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia.
  Kometani M, Yoneda T, Demura M, Koide H, Nishimoto K, Mukai K, Gomez-Sanchez CE, Akagi T, Yokota T, Horike SI, Karashima S, Miyamori I, Yamagishi M, Takeda Y. Sci Rep. 2017;7(1):11205. (査読あり)
• Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study.
  Karashima S, Kometani M, Tsujiguchi H, Asakura H, Nakano S, Usukura M, Mori S, Ohe M, Sawamura T, Okuda R, Hara A, Takamura T, Yamagishi M, Nakamura H, Takeda Y, Yoneda T. Clin Exp Hypertens. 2017 Jul 19:1-8. (査読あり)
• Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis.
  Karashima S, Tsuda T, Wakabayashi Y, Kometani M, Demura M, Ichise T, Kawashiri MA, Takeda Y, Hayashi K, Yoneda T. J Endocr Soc. 2017 Dec 6;2(2):135-139. (査読あり)
• Trajectories of Postload Plasma Glucose in the Development of Type 2 Diabetes in Japanese Adults.
  Oka R, Shibata K, Sakurai M, Kometani M, Yamagishi M, Yoshimura K, Yoneda T. J Diabetes Res. 2017;2017: 5307523. (査読あり)
• Response to the letter "One-hour plasma glucose as a predictor of type 2 diabetes mellitus"
  Oka R, Aizawa T, Miyamoto S, Yoneda T, Yamagishi M. Diabet Med. 2017 May;34(5):734(査読あり)
• Renal glucosuria is not associated with atherosclerotic cardiovascular disease outcome in a general Japanese community.
  Tada H, Kawashiri MA, Sakata K, Yoneda T, Yasuda K, Yamagishi M, Hayashi K. Atherosclerosis. 2017; 261:111-116. (査読あり)
• PEP-on-DEP: A competitive peptide-based disposable electrochemical aptasensor for renin diagnostics.
  Biyani M, Kawai K, Kitamura K, Chikae M, Biyani M, Ushijima H, Tamiya E, Yoneda T, Takamura Y. Biosens Bioelectron. 2016; 84:120-5
• One-hour plasma glucose as a predictor of the development of Type 2 diabetes in Japanese adults. (査読あり)
  Oka R, Aizawa T, Miyamoto S, Yoneda T, Yamagishi M. Diabet Med. 2016 Oct;33(10):1399-405.
• Angiotensin II receptor blocker combined with eplerenone or hydrochlorothiazide for hypertensive patients with diabetes mellitus.
  Karashima S, Yoneda T, Kometani M, Ohe M, Mori S, Sawamura T, Furukawa K, Yamagishi M, Takeda Y. Clin Exp Hypertens. 2016;38(7):565-570. (査読あり)
• The Long-term Effect of Adrenal Arterial Embolization for Unilateral Primary Aldosteronism on Cardiorenovascular Protection, Blood Pressure, and the Endocrinological Profile.
  Kometani M, Yoneda T, Demura M, Karashima S, Mori S, Oe M, Sawamura T, Okuda R, Yamagishi M, Takeda Y. Intern Med. 2016;55(7):769-73. (査読あり)
• Impact of New Quick Gold Nanoparticle-Based Cortisol Assay During Adrenal Vein Sampling for Primary Aldosteronism.
  Yoneda T, Karashima S, Kometani M, Usukura M, Demura M, Sanada J, Minami T, Koda W, Gabata T, Matsui O, Idegami K, Takamura Y, Tamiya E, Oe M, Nakai M, Mori S, Terayama N, Matsuda Y, Kamemura K, Fujii S, Seta T, Sawamura T, Okuda R, Takeda Y, Hayashi K, Yamagishi M, Takeda Y. J Clin Endocrinol Metab. 2016 Jun;101(6):2554-61. (査読あり)
• Comparison of eplerenone and spironolactone for the treatment of primary aldosteronism.
  Karashima S, Yoneda T, Kometani M, Ohe M, Mori S, Sawamura T, Furukawa K, Seta T, Yamagishi M, Takeda Y. Hypertens Res. 2016 Mar;39(3):133-7. (査読あり)
• Dynamic CCAAT/enhancer binding protein (CEBP)-associated changes of DNA methylation in the angiotensinogen gene.
  Wang F , Dr. Cheng Y, Zhu A , Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y. Hypertension. 2014; 63(2):281-8. (査読あり)

著書

• 米田　隆、米谷充弘、臼倉幹哉
  原発性アルドステロン症診療マニュアル改訂第3版:第3章　診断、D副腎静脈サンプリング、術中迅速コルチゾール測定の臨床応用　116-117,2017
  Representations of Psychological Functions of Peer Support Services for Diabetic Patients, Semantic Technology, Volume 8943 of the series Lecture Notes in Computer Science pp 311-318 2015Takeda Y ,Demura M, Yoneda T, Medical Treatment of Primary Aldosteronism, Primary Aldosteronism, pp 209-214 2014
  Osawa I, Ikeda M, Yoneda T, Takeda Y, Nakai M, Usukura M,Abe K,
• 米谷充弘、米田　隆
  臨床化学、原発性アルドステロン症診断の進歩、副腎静脈サンプリングにおける迅速コルチゾール測定の有用性
  Vol. 46　No.1、pp22-27,2017

特許権等知的財産権の取得及び申請状況

• 国内特許（第5590651号）「血液資料の品質評価方法」
• 米国特許 (US 8927219) 「Method for evaluation of quality of blood sample」

診療ガイドライン・政策提言等

• 原発性アルドステロン症ガイドライン作成委員（日本内分泌学会 平成23年12月～現在）
• 自民党　データヘルス推進特命委員会 第４回国民・患者視点のデータヘルスＷＧ 登壇

獲得資金

• 令和2年度　厚生労働科学研究費(循環器疾患・糖尿病等生活習慣病対策総合研究事業)
  〜オンライン特定保健指導・オンライン診療におけるPHR活用による行動変容に関する研究〜
• IoT等活用行動変容研究事業(H30~31 AMED)
  生活習慣病に対するオンライン保健指導サービスの構築と行動変容への検証研究
• 医工連携事業化推進事業(H29～H31 AMED)
  AVSキット等の国際的普及とFDA/TGA取得のための開発事業（児玉崇）
• 基盤研究(C)(H29～H31, 科学研究費補助金)
  生活習慣病における多機能携帯電話を用いた遠隔診療システムの構築（米田隆）
• 石川県次世代産業創造事業補助金(H29,石川県)
  在宅医療のモバイル型簡易測定システムの実用化
• 金沢大学附属病院臨床研究助成費(H26～H29, 金沢大学)
  迅速コルチゾール測定キットの国内外における薬事承認のための臨床研究
• 戦略的基盤技術高度化支援事業(H26～H27,中小企業庁(経産省))
  診断市場のPOCT化に資する新規蛍光剤を用いた高感度POCT装置の開発
• 基盤研究(C)(H25～H28,科学研究費補助金)
  地域医療における軽症糖尿病患者に対する在宅健康サービスの継続研究
• NEDO(H25,新エネルギー産業技術総合開発機構)
  副腎静脈サンプリングの成功率を高めるデバイスとリーダーの開発
• 基盤研究(C)(H22～H24,科学研究費補助金)
  地域医療における軽症糖尿病患者に対する在宅健康サービスの構築
• ふるさと携帯創出推進事業(H21年度(総務省))
  軽症の糖尿病患者に対する在宅健康サービスの構築